Basic Training 4th Annual ICP Conference
Container Materials
Container Material
Impurities found, ng/125mL Bottle
LDPE HDPE
~50
• Virtually all IV products are packaged in either low-density polyethylene (LDPE) or borosilicate bottles/containers • LDPE has consistently come up cleaner than high-density polyethylene (HDPE), polypropylene (PP), and even Teflon® (PTFE). • Borosilicate bottles are used for certain chemical stability considerations. • Leaching with 1-5% HNO 3 is recommended for cleaning bottles.
~250 ~700 ~240
PP
PTFE
Borosilicate
~57500
Container Materials
LDPE • Preferred for its cleanliness • Compatible with all matrices used in our standards
Borosilicate • Used for products containing ≤ 200 ppm Hg and/or < 10 ppm Pd in HNO 3 matrices. • Avoid using HF matrices due to the acid’s attack on glass • Due to impurities, not recommended for solutions containing lower levels of Na, Al, B, Ba, Ca, Fe, K, Ni, Sr, Zn and/or Zr
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