170135_inorganicventures_flipping

17.22 Method Validation

The final step...an ‘Independent Samples t Test’

Cer=fied Value

Cer=fied Value

Independent Samples t Test

Uncertainty Budget

Uncertainty Budget

The ‘Independent Samples t Test ’ is performed to show agreement between the two independently Cer7fied Values. • If there is no agreement, one or both methods has an error. • Iden7fica7on of the error(s) must occur before release of the CRM. • Or the CRM is released as method specific

Q C

Q C

Validated Method #2

Validated Method #1

17.23 Method Validation

Confirm Basic Performance Criteria : Repeatability

• Repeatability (single laboratory precision) can be ini3ally based upon one homogeneous sample and is measured by the laboratory developing the method. • The repeatability is expressed as standard devia3on.